Arsenal will again face Bayern Munich in the knock phase of the 2016/17 UEFA Champions League campaign while dethroned champions Barcelona will tackle Ligue 1 side Paris Saint-Germain.
Wenger's side have encountered the Bundesliga champions four times in the previous five campaigns and finished behind them in the group stage last season.
In other fixtures, EPL Champions Leicester City will play Europa League Champions Sevilla and Manchester City are up against Monaco in the Champions League last 16.
One of the other standout ties of the round puts Spanish champions Barcelona against French champions Paris St-Germain. Barca beat PSG in the quarter-finals en route to winning the title during the 2014-15 season.
Champions and La Liga leaders Real Madrid face Italian side Napoli, who are fourth in Serie A.Full draw
Manchester City v Monaco
Real Madrid v Napoli
Benfica v Borussia Dortmund
Bayern Munich v Arsenal
FC Porto v Juventus
Bayer Leverkusen v Atletico Madrid
Paris St-Germain v Barcelona
Sevilla v Leicester(First legs to be played on 14 & 15 and 21 & 22 February 2017; second legs on 7 & 8 and 14 & 15 March)