Ludogorets will be participating for their sixth consecutive season in the Europa League following their elimination from the Champions League third round.
Ludogorets have now equalled PSV record for the most appearance in the Europa League when they face AS Roma.
AS Roma will start the campaign with a clear objective to win, with Jose Mourinho at the helm of control at the club.
Roma has progressed beyond the group stage in their last four appearances.
The Bulgarian Champions have been in tremendous form in the domestic scene having won the domestic league title for eleven consecutive seasons.
The host has shown great form so far this season having gone five games unbeaten in the domestic scene including the 6-0 win over Hebar at the weekend.
Ludogorets have scored 19 goals in their last five games and would be capable of scoring at least a goal against Mourinho’s side.
This would be the first clash between both teams as no previous record was found.
The team from the Italian capital suffered a shock result at the weekend following the 4-0 defeat against Udinese in the Serie A.
AS Roma won three of their last five games with the other two matches ending in a draw and a defeat
AS Roma would aim to bounce back and reclaim their spot as one of the best teams in this competition.
The inaugural winners of the conference league will not go down without a fight.