Plzen will look to adjust from their 5-1 defeat against Barcelona on matchday one when they face Inter Milan for their second group stage game.
Inter Milan will also aim to avoid a defeat against the Czech team following their 2-0 defeat against Bayern Munich in their previous game when they travel to take on Plzen.
Their record of 34-game unbeaten in the competitive streak came to an end against Barcelona last week.
Plzen will have to defeat Inter Milan to remain competitive having suffered a heavy defeat against Barcelona.
Plzen bounced back from the defeat against Barcelona with a win over Sigma Olomouc with a 3-2 win, they have won four of their last five games.
The Serie A team will be keen on victory against Plzen having recorded a late win against Torino.
Though the form of the Italian team is nothing to write home about with just two wins and three defeats.
Inter Milan will have to take the game to Plzen if they must qualify for the next stage.