RB Leipzig stunned Borussia Dortmund 3-0 in the Bundesliga encounter on Saturday to hand the Black and Yellow their first defeat of the season and winning debut for coach Marco Rose.
Rose replaced Domenico Tedesco earlier this week after a bad start to the league season and a 4-1 loss at home to Shakhtar Donetsk in the Champions League this week.
Willi Orban put RB Leipzig ahead with a header off the corner in the sixth minute before former Chelsea striker Timo Werner could have doubled the advantage.
However, Dominik Szoboszlai get the home side their second goal before one-time Manchester United transfer Amadou Haidara ensure the maximum points for new and former Dortmund manager Rose.
Leipzig move up to eight points in 10th place as the host will travel to Real Madrid in the Champions League next week.